mdd ir initial: 20 mg PO once daily
mdd ir titration: Increase by 10 to 20 mg/day at intervals of ≥1 week based on response and tolerability
mdd ir typical: 20 to 40 mg/day
mdd ir max: 50 mg/day
mdd er initial: 25 mg PO once daily
mdd er titration: Increase by 12.5 mg/day at intervals of ≥1 week based on response and tolerability
mdd er typical: 25 to 50 mg/day
mdd er max: 62.5 mg/day
gad ir initial: 10 to 20 mg PO once daily
gad ir titration: Increase by 10 mg/day at intervals of ≥1 week based on response and tolerability
gad ir max: 50 mg/day
panic ir initial: 10 mg PO once daily for 3 to 7 days
panic ir titration: Increase by 10 mg/day at intervals of ≥1 week based on response and tolerability
panic ir typical: 20 to 40 mg/day
panic ir max: 60 mg/day
panic er initial: 12.5 mg PO once daily
panic er titration: Increase by 12.5 mg/day at intervals of ≥1 week based on response and tolerability
panic er max: 75 mg/day
ocd ir initial: 20 mg PO once daily
ocd ir titration: Increase by 10 mg/day at intervals of ≥1 week based on response and tolerability
ocd ir typical: 40 to 60 mg/day
ocd ir max: 60 mg/day (some specialists use higher doses when tolerated, with careful risk/benefit)
ptsd ir initial: 20 mg PO once daily
ptsd ir titration: Increase by 10 to 20 mg/day at intervals of ≥1 week based on response and tolerability
ptsd ir max: 60 mg/day
social anxiety ir initial: 10 to 20 mg PO once daily
social anxiety ir titration: After 4 to 6 weeks at the initial dose, increase by 10 mg/day at intervals of ≥1 week as needed based on response and tolerability
social anxiety ir max: 60 mg/day
social anxiety er initial: 12.5 to 25 mg PO once daily
social anxiety er titration: After 4 to 6 weeks at the initial dose, increase by 12.5 mg/day at intervals of ≥1 week as needed based on response and tolerability
social anxiety er max: 37.5 mg/day (some specialists use higher equivalent doses when needed, with careful risk/benefit)
pmdd er continuous initial: 12.5 mg PO once daily (continuous daily dosing)
pmdd er continuous titration: Increase to 25 mg once daily over the first month; in a subsequent cycle may increase further based on response
pmdd er continuous max: 50 mg/day (based on equivalent IR dose)
pmdd ir continuous offlabel initial: 10 mg PO once daily (continuous daily dosing)
pmdd ir continuous offlabel titration: Increase to 20 mg once daily over the first month; in a subsequent cycle may increase further based on response
pmdd ir continuous offlabel max: 40 mg/day
pmdd ir luteal offlabel initial: 10 mg PO once daily during the luteal phase only (start ~14 days before anticipated menses and continue to onset of menses)
pmdd ir luteal offlabel titration: Increase to 20 mg once daily during luteal phase over the first month; in a subsequent cycle may increase further based on response
pmdd ir luteal offlabel max: 30 mg/day during luteal phase
pmdd er luteal initial: 12.5 mg PO once daily during the luteal phase only (start ~14 days before anticipated menses and continue to onset of menses)
pmdd er luteal titration: Increase to 25 mg once daily during luteal phase over the first month; in a subsequent cycle may increase further based on response
pmdd er luteal max: 37.5 mg/day during luteal phase (based on equivalent IR dose)
pmdd ir symptom onset offlabel: 10 mg PO once daily from symptom onset until a few days after start of menses; may increase based on response up to 20 mg/day, and in later cycles up to 30 mg/day if needed
bdd ir offlabel initial: 20 mg PO once daily
bdd ir offlabel titration: Increase by 20 mg/day every 2 to 3 weeks based on response and tolerability
bdd ir offlabel typical: 60 mg/day
bdd ir offlabel max: 100 mg/day (specialist-level dosing when tolerated, if needed for optimal response)
sensitive patient low start: Some experts start lower (IR 5 to 10 mg once daily or ER 12.5 mg once daily) and titrate gradually, especially in anxiety-sensitive patients who get overstimulated early (anxiety, insomnia).
dosing conversion note: IR and ER are not interchangeable mg-for-mg; a commonly cited conversion is IR 10 mg ≈ ER 12.5 mg.