👶Pregnancy
Contraindicated in labeling: pregnancy. Benzodiazepines have potential fetal risks, and late-pregnancy exposure can cause neonatal sedation and/or withdrawal. For insomnia in pregnancy, nonpharmacologic treatment (like CBT-I) is typically preferred, and medication choices should be individualized with obstetric and psychiatric input. Encourage enrollment in the National Pregnancy Registry for Psychiatric Medications (1-866-961-2388) if exposure occurs.🤱Breastfeeding
Not recommended by the manufacturer. It is not clearly established how much flurazepam transfers into milk, but the long half-life increases concern for infant sedation, feeding issues, poor weight gain, and withdrawal effects. Consider alternative treatments and consult pediatric guidance if exposure occurs.👧Children & Adolescents (Under 18)
Limited data: Adolescents ≥15 years have been reported to use 15 mg at bedtime in limited settings. In general, benzodiazepine hypnotics are rarely preferred in pediatric populations due to paradoxical reactions, misuse risk, and safety concerns.👴Older Adults (65+)
Avoid use in adults ≥65 whenever possible. Older adults have increased sensitivity and decreased clearance of long-acting benzodiazepines, raising risk for confusion, delirium, falls, fractures, and motor vehicle accidents. If a benzodiazepine hypnotic is being considered in an older adult, clinicians typically look for safer alternatives first.🔬Liver Impairment
No specific adjustment provided in manufacturer labeling; use with caution. Reduced hepatic function can increase sedation and prolong effects.💧Kidney Impairment
No specific adjustment provided in manufacturer labeling; use with caution. Dose adjustment is generally unlikely based on limited urinary excretion of parent drug, but overall sensitivity and accumulation risk still matter—especially in frail patients.