Indications
Primary Indications
Treatment-resistant depressionGeneralized anxietyAddiction (alcohol, tobacco, other substances)Palliative/end-of-life distress
Experimental psychedelic-assisted therapy using N,N-dimethyltryptamine (DMT), a short-acting psychedelic.
Studies are exploring whether it could help depression, anxiety, addiction and distress at the end of life; it is only available in research studies.
Reviewed by the HeyPsych Medical Review Board · Reviewed November 24, 2025
Choose a condition to see how it's used for it.
Used for
Common use
DMT-Assisted Therapy is used for Major Depressive Disorder. The full guide below has the details.
About Major Depressive DisorderHow many people in 100 notice each one in clinical studies. Many early side effects fade within a few weeks.
Persistent perceptual disturbances
Triggering psychotic episode in vulnerable individuals
Thoughts of suicide? Call or text 988, any time.
Everything we know about DMT-Assisted Therapy, section by section.
9 chapters · about 9 min to read it all. Open any one.
Frequency: Single or repeated sessions, depending on trial design
Duration: Core psychedelic effects last minutes; total therapeutic session ~1–2 hours
Total Treatment Time: Varies; often several sessions including prep and integration
typical session cost: Unknown; investigational only
total treatment cost: Projected to be moderate-to-high due to clinical monitoring
insurance coverage: Not covered; research context only
Limited sample sizes; short follow-up durations; optimal protocols (dose, frequency) not yet established.
This treatment information is for educational purposes only. Treatment decisions should be made in consultation with qualified healthcare professionals based on individual circumstances, symptoms, and medical history. Do not attempt treatment without professional guidance.
Thinking about DMT-Assisted Therapy? A prescriber can tell you if it fits.
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