Indications
Primary Indications
Major depressive disorder (including treatment-resistant subgroups)Anxiety disorders and end-of-life/existential distressPost-traumatic stress disorder (PTSD)Substance use disorders as an adjunct to psychotherapy
An experimental psychedelic-assisted therapy using 5-MeO-DMT, a short-acting psychedelic that can cause intense altered states of mind.
When combined with preparation and integration therapy, it may help several conditions, but it is still being studied and is only available in research studies.
Reviewed by the HeyPsych Medical Review Board · Reviewed November 24, 2025
Choose a condition to see how it's used for it.
Used for
Also prescribed for (off-label)
Common use
5-MeO-DMT Therapy is used for Depression. The full guide below has the details.
About DepressionHow many people in 100 notice each one in clinical studies. Many early side effects fade within a few weeks.
Choose what applies to you.
Should not be used during pregnancy
General information, not advice for your case. Talk it through with your prescriber or pharmacist.
in people who are vulnerable
Medical complications in those with occult cardiovascular disease
Thoughts of suicide? Call or text 988, any time.
Everything we know about 5-MeO-DMT Therapy, section by section.
15 chapters · about 15 min to read it all. Open any one.
Frequency: Typically 1 session; some protocols allow 1–2 additional sessions several weeks apart
Duration: Psychedelic effects peak within minutes and resolve within 30–45 minutes; observation continues for 1–2+ hours
Total Treatment Time: 2–8 weeks including preparation and integration
Intention setting, review of coping strategies, mindfulness or breath training, safety check
De-brief, hydration/snack, initial integration conversation, safety assessment for discharge
typical session cost: Not standardized; in clinical research, medication is typically provided under protocol
total treatment cost: Varies by study and number of therapy visits; may include screening and integration sessions
insurance coverage: Investigational—coverage generally unavailable outside approved research
cost effectiveness: Unknown pending definitive efficacy and durability data
Limited RCT data; variable set/setting and dosing across contexts; safety requires rigorous screening and medical readiness.
This treatment information is for educational purposes only. Treatment decisions should be made in consultation with qualified healthcare professionals based on individual circumstances, symptoms, and medical history. Do not attempt treatment without professional guidance.
Thinking about 5-MeO-DMT Therapy? A prescriber can tell you if it fits.
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