Indications
Primary Indications
Insomnia (particularly delayed sleep onset)Jet lagShift work sleep disorderDelayed sleep phase syndromeAdjunctive use in anxiety or depression (off-label)
Melatonin is a naturally occurring hormone produced by the pineal gland that regulates circadian rhythms and sleep-wake cycles.
Supplementation is widely used for insomnia, jet lag, and circadian rhythm disorders.
Reviewed by the HeyPsych Medical Review Board · Reviewed November 24, 2025
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Used for
Also prescribed for (off-label)
Common use
Melatonin is used for Insomnia (sleep onset). The full guide below has the details.
How many people in 100 notice each one in clinical studies. Many early side effects fade within a few weeks.
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Not recommended—safety data insufficient
General information, not advice for your case. Talk it through with your prescriber or pharmacist.
Exacerbation of autoimmune conditions (theoretical)
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Everything we know about Melatonin, section by section.
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With: CNS depressants
Risk: Additive sedation
Action: Monitor for drowsiness
With: Anticoagulants/antiplatelet drugs
Risk: Potential increased bleeding risk
Action: Monitor closely
With: Immunosuppressants
Risk: May counteract effects
Action: Use caution
This treatment information is for educational purposes only. Treatment decisions should be made in consultation with qualified healthcare professionals based on individual circumstances, symptoms, and medical history. Do not attempt treatment without professional guidance.
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