Borage Oil

Reviewed by the HeyPsych Medical Review Board

Board-certified psychiatrists and mental health professionals

Published August 17, 2025•Updated February 20, 2026•Reviewed February 20, 2026

Indications

Primary Indications

Atopic dermatitis and eczema managementPMS-related breast tenderness, irritability, and bloatingRheumatoid arthritis symptom reliefGeneral skin and hair health

Mechanism

Borage oil contains high levels of gamma-linolenic acid (GLA), which is converted into dihomo-γ-linolenic acid (DGLA). This leads to the production of anti-inflammatory prostaglandins and reduced synthesis of pro-inflammatory eicosanoids. These effects improve skin barrier function, reduce inflammation, and support hormonal balance. Preliminary research suggests GLA may also influence neuronal signaling and stress response.

Dosing

Adult Dosing

note: Divided doses with food recommended for best absorption.

typical: 500–2000 mg daily (providing 100–400 mg GLA)

Dosage Forms

Softgel capsules
Liquid oil

Onset Duration

Improvements in skin and PMS symptoms may take 6–12 weeks of continuous use. Anti-inflammatory benefits build gradually over time.

Adverse Effects

Common Side Effects

• GI upset

• Loose stools

• Belching with oil taste

⚠️ Serious Side Effects

Rare hepatotoxicity from pyrrolizidine alkaloids if oil is not properly purified

Warnings

Critical Safety Information

→Ensure supplements are certified PA-free to reduce risk of liver toxicity.
→Avoid use in patients with active liver disease or significant hepatic impairment.

Interactions

With: Warfarin and anticoagulants

Risk: Increased bleeding risk

Action: Monitor INR closely

With: Antiplatelet drugs

Risk: Additive bleeding effect

Action: Monitor clinical response

With: Hepatotoxic medications

Risk: Increased liver burden

Action: Avoid or monitor liver function

Monitoring

Skin symptom response
PMS symptom tracking
Liver function (if long-term)
Signs of bleeding

Special Populations

👶Pregnancy

Not recommended; insufficient data on safety

🤱Breastfeeding

Limited safety evidence; avoid unless supervised

👧Children & Adolescents (Under 18)

Not well studied

👴Older Adults (65+)

Generally safe; monitor for polypharmacy and bleeding risk

Tapering

Not required; discontinuation may lead to gradual return of symptoms.

Clinical Notes

Borage oil contains the highest GLA concentration among seed oils, higher than evening primrose and black currant oil.
Choose certified PA-free borage oil to minimize hepatotoxicity risk.
May serve as an alternative for patients not responding to evening primrose or black currant oil supplementation.

This treatment information is for educational purposes only. Treatment decisions should be made in consultation with qualified healthcare professionals based on individual circumstances, symptoms, and medical history. Do not attempt treatment without professional guidance.

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