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HomeConditionsDepression & Bipolar (Mood Disorders)Substance/Medication-Induced Depressive Disorder
Mental Health Condition

Substance/Medication-Induced Depressive Disorder

Overview

Description

A depressive syndrome in which low mood, anhedonia, and related neurovegetative and cognitive symptoms arise during or soon after substance intoxication, withdrawal, or exposure to a medication known to produce such effects. The depressive disturbance is temporally related to the substance/medication, causes clinically significant distress or impairment, and is not better explained by a primary depressive disorder.

Prevalence

Varies with substance class, dose, duration, and vulnerability; common with alcohol, sedatives, opioids, and during stimulant or benzodiazepine withdrawal; also reported with several prescription agents.

Age of Onset

Any age, dictated by timing of exposure; often emerges in late adolescence through mid-adulthood when substance use and medication exposures are more common.

DSM-5 Code

F32.89 (other specified depressive disorder due to substance/medication)

ICD-10 Code

F1x.94 (psychoactive substance-induced mood disorder, depressive type)

Reviewed by the HeyPsych Medical Review Board
Board-certified psychiatrists and mental health professionals
Medical Review Board
Published: August 15, 2025
Last Updated: January 9, 2026
Last Reviewed: January 9, 2026

Diagnostic Criteria

Symptoms

Prognosis

Evaluation

Specifiers

Neurobiology

Risk Factors

Comorbidities

Warning Signs

Impact On Life

Severity Levels

Treatment Goals

Prognosis Factors

When To Seek Help

Real Life Examples

Developmental Stages

Self Help Strategies

Treatment Approaches

Overdiagnosis Factors

Missed Diagnosis Factors

This information about mental health conditions is for educational purposes only. If you believe you may be experiencing symptoms of a mental health condition, please consult with a qualified healthcare professional for proper evaluation and diagnosis.

Seeking Help for Substance/Medication-Induced Depressive Disorder?

If you recognize these symptoms in yourself or a loved one, know that help is available. Mental health conditions are treatable with options like Cognitive Behavioral Therapy, and early intervention can make a significant difference.
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