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HomeConditionsDepression & Bipolar (Mood Disorders)Depressive Disorder Due to Another Medical Condition
Mental Health Condition

Depressive Disorder Due to Another Medical Condition

Overview

Description

A mood disturbance characterized by persistent depressed mood and/or markedly diminished interest or pleasure that is judged to be the direct pathophysiological consequence of another medical condition. Symptoms cause clinically significant distress or impairment, are not better explained by another mental disorder, and do not occur exclusively during delirium.

Prevalence

Varies by underlying condition; elevated rates in neurological disorders (stroke, Parkinson’s disease, multiple sclerosis, epilepsy, TBI), endocrine disorders (hypothyroidism, Cushing’s), chronic inflammatory/infectious diseases, malignancy, sleep apnea, and chronic pain conditions.

Age of Onset

Any age depending on onset of the medical condition.

DSM-5 Code

F06.31 (with depressive features), F06.32 (with major depressive-like episode), F06.34 (with mixed features when applicable)

ICD-10 Code

F06.31/F06.32

Reviewed by the HeyPsych Medical Review Board
Board-certified psychiatrists and mental health professionals
Medical Review Board
Published: August 15, 2025
Last Updated: January 9, 2026
Last Reviewed: January 9, 2026

Diagnostic Criteria

Symptoms

Prognosis

Evaluation

Specifiers

Neurobiology

Risk Factors

Comorbidities

Warning Signs

Impact On Life

Severity Levels

Treatment Goals

Prognosis Factors

When To Seek Help

Real Life Examples

Developmental Stages

Self Help Strategies

Treatment Approaches

Overdiagnosis Factors

Missed Diagnosis Factors

This information about mental health conditions is for educational purposes only. If you believe you may be experiencing symptoms of a mental health condition, please consult with a qualified healthcare professional for proper evaluation and diagnosis.

Seeking Help for Depressive Disorder Due to Another Medical Condition?

If you recognize these symptoms in yourself or a loved one, know that help is available. Mental health conditions are treatable with options like Cognitive Behavioral Therapy, and early intervention can make a significant difference.
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