Contrave (Naltrexone/Bupropion): Psychiatric Warnings, Side Effects, Dosing & Opioid Risks

What It's Used For

Contrave is FDA-approved for chronic weight management (with diet + exercise). It is NOT approved for major depressive disorder or other psychiatric disorders—even though it contains bupropion (an antidepressant ingredient). In psychiatry, the most relevant use-case is when weight/metabolic health is part of the mental health picture (for example, weight gain on psych meds), but that’s not the official indication.

Primary Indications

Chronic weight management: adjunct to reduced-calorie diet + increased physical activityEligibility (typical): BMI ≥30 kg/m², or BMI ≥27 kg/m² with at least one weight-related comorbidity (eg, dyslipidemia)Treatment continuation check: consider stopping if <4% to 5% weight loss after ~3 months

Off-Label Uses

Weight gain in people taking psychiatric medications (clinical practice consideration, not FDA-approved)Reward-driven cravings / compulsive overeating patterns (not FDA-approved for binge eating disorder)

How Fast It Works

Contrave is titrated up weekly, so the “effect” usually ramps rather than hitting all at once. The weight loss is gradual, but side effects (especially nausea, insomnia, jitteriness) can show up early.

Week 1

Many people notice nausea, headache, insomnia, or a “wired” feeling before they notice major craving changes

Weeks 2-4

Appetite/craving effects often become more noticeable as dosing increases

First 1-2 months

Highest-risk window for mood worsening or suicidal thoughts (especially in younger adults) and for anxiety/insomnia flare-ups

Around 3 months

If you haven’t lost ~4-5% of baseline weight, it may not be the right tool—discuss stopping

Safe Discontinuation

Contrave is not a serotonergic antidepressant, so classic SSRI-style discontinuation symptoms are less likely. Still, if you’ve been on it for a while, tapering helps you monitor what returns (cravings, appetite, mood, energy, sleep) and reduces the chance of “rebound” discomfort.

Key Points

If therapy has lasted ≥4 weeks: consider tapering over ~2 to 4 weeks so you can detect reemerging symptoms and avoid abrupt shifts in sleep/mood/appetite.
If therapy lasted 2 to 3 weeks: tapering over ~1 to 2 weeks is reasonable.
If therapy lasted <2 weeks: a taper is often not necessary, but discuss with your prescriber if you had strong activation (insomnia/anxiety) or other significant side effects.
Withdrawal symptoms from abrupt discontinuation are less likely than with serotonergic antidepressants because bupropion has minimal serotonergic activity.
If stopping because of serious psychiatric symptoms (suicidality, mania, psychosis, severe agitation): stopping sooner may be necessary—this should be clinician-guided.

Dosing Information

Adult Dosing

weight management initial: Week 1: 1 tablet (naltrexone 8 mg/bupropion 90 mg) PO once daily in the morning

weight management titration: Increase weekly as tolerated: Week 2: 1 tablet PO BID; Week 3: 2 tablets AM + 1 tablet PM; Week 4 and onward: 2 tablets PO BID

weight management max: Maximum 4 tablets/day total (naltrexone 32 mg/bupropion 360 mg per day); no more than 2 tablets per dose

Simple Explanation

This med is built to ramp up slowly. The slow weekly increase is there for a reason: it reduces side effects and helps lower seizure risk. If you miss doses, don’t “catch up” by doubling—just restart safely with your prescriber’s guidance.

Available Formulations

Extended-Release Tablet (12-hour): naltrexone HCl 8 mg / bupropion HCl 90 mg
Administration: Typically taken twice daily (morning and evening) after titration; do not cut, chew, or crush
Food note: Do not take with high-fat meals

Critical Safety Information

If mood worsens or suicidal thoughts show up—especially early on or with dose changes—treat it as urgent.

→Do not take if you use opioids (including buprenorphine or methadone) unless your prescriber has clearly planned a safe opioid-free interval.
→If you feel more agitated, panicky, sleepless, impulsive, or your mood gets darker—tell your prescriber immediately. Don’t tough it out.
→Take exactly as titrated. Do not double doses if you miss one. Do not take more than 2 tablets at a time.
→Avoid high-fat meals with dosing. This can increase medication exposure and side effects.
→Know your seizure risk: history of seizures, eating disorders, heavy alcohol use, or abrupt sedative withdrawal makes this medication unsafe.
→Check blood pressure before starting and periodically after—especially in the first 3 months.

Side Effects

Most common: nausea, constipation, headache, dizziness, and sleep problems. Psych-relevant side effects include insomnia, anxiety/jitteriness, irritability, mood changes, and (rarely) severe neuropsychiatric symptoms.

Common Things People Notice

Nausea (very common)
Constipation (common)
Headache (common)
Dizziness (common)
Sleep disturbance / insomnia (common)
Anxiety or jitteriness (can happen, especially early)

Common Side Effects

33%

Nausea— This is the top complaint. It often hits early during titration and may fade over time. Taking it as directed (and not with high-fat meals) can help.

19%

Constipation— Hydration, fiber, and a simple bowel plan matter. If constipation is severe or painful, don’t ignore it.

18%

Headache— Often shows up during dose changes. If headaches are severe, persistent, or paired with high blood pressure symptoms, get checked.

9% to 14%

Sleep disturbance / Insomnia— This can feel like trouble falling asleep, waking up early, or “light sleep.” If you’re already an anxious/insomniac type, this side effect can be the dealbreaker.

10%

Dizziness— Can be worse if you’re dehydrated, not eating regularly, or sensitive to activation. Stand up slowly; report presyncope/fainting.

Anxiety 4% to 6%; irritability 3%; tremor 4%

Anxiety / Jitteriness / Irritability— Bupropion can feel activating. Mild activation can be manageable; escalating panic, agitation, or aggressive irritability is a stop-and-reassess moment.

Depressed mood— Any new or worsening depression—especially with suicidal thoughts—needs prompt attention, particularly during the first 1-2 months or after dose changes.

Serious side effects

Suicidal thoughts/behavior (highest monitoring need in younger adults and during dose changes): urgent evaluation required
Seizures (dose-related risk from bupropion): permanently discontinue if seizure occurs
Severe neuropsychiatric reactions (rare): psychosis, hallucinations, paranoia, severe agitation, hostility, homicidal ideation—stop medication and seek urgent care
Hypertensive reactions or significant BP/HR increases: evaluate promptly
Acute opioid withdrawal (if opioids are in the system): can be severe; avoid unsafe opioid overlap
Hepatotoxicity (naltrexone-related reports): stop if signs/symptoms of hepatitis develop
Severe hypersensitivity reactions (rare): anaphylaxis/angioedema; severe skin reactions reported with bupropion

Critical Drug Interactions

This medication is a combo of an opioid blocker (naltrexone) and an activating antidepressant ingredient (bupropion). Interactions matter—especially anything that affects opioids, seizure risk, or monoamine systems.

With: Opioids (including buprenorphine, methadone, and opioid pain medications)

Risk: Can precipitate acute opioid withdrawal and block opioid analgesia. Attempts to overcome blockade with high opioid doses can cause fatal overdose.

Action: Avoid opioid use. If opioid therapy is required, stop Contrave under prescriber guidance. If opioids are restarted after naltrexone exposure, lower doses may have stronger-than-expected effects—overdose risk is real.

With: MAOIs (and within 14 days of MAOI use)

Risk: Serious interaction risk with bupropion; must not be combined. Contrave also must not be started in someone receiving linezolid or IV methylene blue (which act like MAOIs).

Action: Allow 14 days between stopping an MAOI and starting Contrave, and 14 days between stopping Contrave (bupropion) and starting an MAOI.

With: Other bupropion-containing products

Risk: Excess bupropion exposure increases seizure risk and adverse effects.

Action: Contraindicated. Do not combine with Wellbutrin (any formulation), Aplenzin, Zyban, or any other bupropion product.

With: Alcohol (especially heavy use or withdrawal risk)

Risk: Bupropion lowers seizure threshold. Abrupt alcohol discontinuation is a seizure risk state and is a contraindication scenario.

Action: Avoid if you’re at risk for alcohol withdrawal. Be honest about drinking patterns before starting.

With: Medications/conditions that raise seizure risk (some antipsychotics, antidepressants, theophylline, systemic corticosteroids, hypoglycemic agents)

Risk: Additive seizure risk and activation side effects (jitteriness, insomnia).

Action: Risk-screen carefully. Dose titration must be gradual; avoid stacking multiple seizure-threshold-lowering agents when possible.

With: High-fat meals

Risk: Significantly increases systemic exposure of bupropion and naltrexone, increasing adverse effect risk.

Action: Do not take with high-fat meals.

With: Thioridazine (Canadian labeling)

Risk: Additional contraindication in Canada.

Action: Avoid combination in settings where this applies.

Pregnancy, Breastfeeding, Special Groups

Weight-loss medications aren’t recommended during pregnancy or breastfeeding. Psychiatric considerations matter here too: mood stability and sleep are already vulnerable in these stages, and this medication can be activating. Use extra caution in older adults and in people with kidney or liver impairment.

👶Pregnancy

Not recommended during pregnancy. Weight loss offers no clinical benefit in pregnancy and may cause fetal harm; discontinue if pregnancy is detected. Information on this specific combination in pregnancy is limited.

🤱Breastfeeding

Not recommended while breastfeeding. Naltrexone, bupropion, and metabolites are present in breast milk; due to safety concerns, weight-loss medications are generally avoided during lactation.

👧Children & Adolescents (Under 18)

Not approved for children and teens. The antidepressant suicide-risk warning applies to children and adolescents; avoid.

👴Older Adults (65+)

Refer to adult dosing, but use caution. Older adults may be at greater risk of drug accumulation during chronic dosing and may be more sensitive to insomnia, blood pressure increases, dizziness, and neuropsychiatric effects.

🔬Liver Impairment

Mild impairment: no dosage adjustment necessary. Moderate impairment: maximum 1 tablet PO BID. Severe impairment: use is not recommended.

💧Kidney Impairment

Mild impairment: no dosage adjustment necessary. Moderate or severe impairment: maximum 1 tablet PO BID. End-stage renal disease: use is not recommended.

Clinical Monitoring

Mood and suicidality: screen for worsening depression, suicidal thoughts, and unusual behavior changes—especially in the first 1-2 months and during dose increases/decreases
Activation symptoms: anxiety, panic symptoms, agitation, irritability, hostility, impulsivity, akathisia-like restlessness
Bipolar risk: screen for bipolar disorder before starting; monitor for hypomania/mania (decreased sleep need, racing thoughts, risky behavior, grandiosity)
Sleep: insomnia severity, sleep fragmentation, and daytime fatigue (sleep disruption can destabilize mood)
Blood pressure and heart rate: baseline and periodic monitoring; risk may be higher during the first 3 months
Weight and BMI: track response and tolerability; reassess continuation at ~3 months
Blood sugar: checked at the start and from time to time if you have diabetes; watch for low blood sugar, because weight loss can make your body respond more strongly to insulin
Kidney and liver function: checked at the start and from time to time, especially if you already have kidney or liver problems
Opioid status: confirm opioid-free interval when relevant; counsel about blocked analgesia and overdose risk if attempting to override blockade
Adverse effects that change functioning: dizziness, cognitive changes, tremor, severe nausea/dehydration, mood symptoms affecting daily life

How Well It Works

Continue-or-Stop Checkpoint

4% to 5% weight loss by ~3 months

vs If below this, consider discontinuation

Contrave isn’t meant to be a “take it forever no matter what” medication. A common approach is: if you’re not down roughly 4-5% of your starting weight after about 3 months, it may not be worth staying on it.

Mechanism of Action

Contrave combines two mechanisms: naltrexone blocks opioid receptors (which can reduce reward signaling tied to cravings), and bupropion weakly inhibits dopamine and norepinephrine reuptake (which can affect motivation, reward, and appetite pathways). The exact neurochemical path to weight loss isn’t fully nailed down, but the big targets are the hypothalamus (appetite regulation) and the mesolimbic dopamine circuit (reward system).

Place in Treatment Algorithm

In psychiatry-adjacent care, Contrave shows up when weight and cravings are harming health—and especially when weight gain is tangled up with psychiatric meds or mood-related eating. But it’s not a “mood med,” and it can destabilize sleep and anxiety in the wrong person. It’s a bad fit for anyone with opioid use, uncontrolled blood pressure, seizure risk, or eating disorder history. If a patient has bipolar-spectrum risk, you treat that risk seriously before using anything with antidepressant-like activation.

Questions people ask

Is Contrave an antidepressant?

Contrave is not approved to treat depression. But it contains bupropion—the same active ingredient used in some antidepressants (like Wellbutrin). That means it can feel activating (more energy, less appetite, more drive) and it can also worsen insomnia, anxiety, or irritability in some people.

Can Contrave help anxiety or depression?

It’s not approved for anxiety or depression, and it’s not prescribed as a primary psychiatric treatment. Some people notice mood/energy changes because of the bupropion component, but others feel worse (more anxious, more wired, more irritable). If you’re struggling with mood symptoms, treat that directly with your clinician rather than hoping Contrave will “cover it.”

Why does Contrave have a suicidality warning?

Because it contains bupropion, which is also used in antidepressants. In short-term trials, antidepressants increased suicidal thoughts and behavior in children, adolescents, and young adults. That’s why the key rule is: monitor closely for worsening mood, suicidal thoughts, or unusual behavior changes—especially early in treatment and during dose changes.

Can Contrave trigger insomnia or feeling “too wired”?

Yes. Insomnia and sleep problems are common. Some people also feel jittery, restless, or more anxious—especially during the weekly dose step-up. If sleep falls apart, mood often follows, so this isn’t a minor side effect for mental health—it can be a reason to stop.

Is Contrave safe if I have bipolar disorder?

Use caution. Anything with antidepressant-like activation can trigger hypomania/mania in bipolar-spectrum patients. If there’s bipolar risk, your clinician should screen carefully first and monitor for red flags: less need for sleep, racing thoughts, impulsive behavior, or unusually elevated/irritable mood.

Can I take Contrave if I use opioid pain meds or take buprenorphine/methadone?

No—this is one of the biggest safety issues. Naltrexone blocks opioids and can trigger withdrawal if opioids are in your system. It can also make opioid pain meds not work. And trying to override the blockade by taking more opioids is dangerous and can lead to fatal overdose.

What’s the dosing schedule for Contrave?

It’s a weekly step-up: Week 1 is 1 tablet in the morning. Week 2 is 1 tablet twice daily. Week 3 is 2 tablets in the morning and 1 in the evening. Week 4 and beyond is 2 tablets twice daily (max 4 tablets/day). Don’t take more than 2 tablets at one time.

How do I know if Contrave is working?

A common checkpoint is around 3 months: if you haven’t lost about 4-5% of your starting weight, it may not be worth continuing—especially if side effects are significant.

Can I stop Contrave suddenly?

Sudden-stop symptoms are less likely than with antidepressants that raise serotonin, but lowering the dose gradually is still reasonable if you’ve been on it for a while—mainly so you can track what returns (sleep issues, cravings, mood changes) and avoid a rough rebound. If you’re stopping because of serious mental health symptoms, your clinician may recommend stopping faster.

Does Contrave raise blood pressure or heart rate?

It can. It should not be used if you have uncontrolled high blood pressure. Blood pressure and heart rate should be checked before starting and from time to time after that—especially in the first 3 months.

Who should NOT take Contrave from a psychiatric safety standpoint?

People with seizure risk, eating disorder history (bulimia/anorexia), uncontrolled hypertension, heavy alcohol use with withdrawal risk, or bipolar-spectrum risk without proper screening/monitoring. And anyone using opioids should avoid it due to the naltrexone component.

What It's Used For

Primary Indications

Off-Label Uses

How Fast It Works

Week 1

Many people notice nausea, headache, insomnia, or a “wired” feeling before they notice major craving changes

Weeks 2-4

Appetite/craving effects often become more noticeable as dosing increases

First 1-2 months

Highest-risk window for mood worsening or suicidal thoughts (especially in younger adults) and for anxiety/insomnia flare-ups

Around 3 months

If you haven’t lost ~4-5% of baseline weight, it may not be the right tool—discuss stopping

Safe Discontinuation

Key Points

If therapy has lasted ≥4 weeks: consider tapering over ~2 to 4 weeks so you can detect reemerging symptoms and avoid abrupt shifts in sleep/mood/appetite.
If therapy lasted 2 to 3 weeks: tapering over ~1 to 2 weeks is reasonable.
If therapy lasted <2 weeks: a taper is often not necessary, but discuss with your prescriber if you had strong activation (insomnia/anxiety) or other significant side effects.
Withdrawal symptoms from abrupt discontinuation are less likely than with serotonergic antidepressants because bupropion has minimal serotonergic activity.
If stopping because of serious psychiatric symptoms (suicidality, mania, psychosis, severe agitation): stopping sooner may be necessary—this should be clinician-guided.

Dosing Information

Adult Dosing

weight management initial: Week 1: 1 tablet (naltrexone 8 mg/bupropion 90 mg) PO once daily in the morning

weight management titration: Increase weekly as tolerated: Week 2: 1 tablet PO BID; Week 3: 2 tablets AM + 1 tablet PM; Week 4 and onward: 2 tablets PO BID

weight management max: Maximum 4 tablets/day total (naltrexone 32 mg/bupropion 360 mg per day); no more than 2 tablets per dose

Simple Explanation

Available Formulations

Extended-Release Tablet (12-hour): naltrexone HCl 8 mg / bupropion HCl 90 mg
Administration: Typically taken twice daily (morning and evening) after titration; do not cut, chew, or crush
Food note: Do not take with high-fat meals

Critical Safety Information

If mood worsens or suicidal thoughts show up—especially early on or with dose changes—treat it as urgent.

→Do not take if you use opioids (including buprenorphine or methadone) unless your prescriber has clearly planned a safe opioid-free interval.
→If you feel more agitated, panicky, sleepless, impulsive, or your mood gets darker—tell your prescriber immediately. Don’t tough it out.
→Take exactly as titrated. Do not double doses if you miss one. Do not take more than 2 tablets at a time.
→Avoid high-fat meals with dosing. This can increase medication exposure and side effects.
→Know your seizure risk: history of seizures, eating disorders, heavy alcohol use, or abrupt sedative withdrawal makes this medication unsafe.
→Check blood pressure before starting and periodically after—especially in the first 3 months.

Side Effects

Common Things People Notice

Nausea (very common)
Constipation (common)
Headache (common)
Dizziness (common)
Sleep disturbance / insomnia (common)
Anxiety or jitteriness (can happen, especially early)

Common Side Effects

33%

Nausea— This is the top complaint. It often hits early during titration and may fade over time. Taking it as directed (and not with high-fat meals) can help.

19%

Constipation— Hydration, fiber, and a simple bowel plan matter. If constipation is severe or painful, don’t ignore it.

18%

Headache— Often shows up during dose changes. If headaches are severe, persistent, or paired with high blood pressure symptoms, get checked.

9% to 14%

10%

Dizziness— Can be worse if you’re dehydrated, not eating regularly, or sensitive to activation. Stand up slowly; report presyncope/fainting.

Anxiety 4% to 6%; irritability 3%; tremor 4%

Anxiety / Jitteriness / Irritability— Bupropion can feel activating. Mild activation can be manageable; escalating panic, agitation, or aggressive irritability is a stop-and-reassess moment.

Depressed mood— Any new or worsening depression—especially with suicidal thoughts—needs prompt attention, particularly during the first 1-2 months or after dose changes.

Serious side effects

Suicidal thoughts/behavior (highest monitoring need in younger adults and during dose changes): urgent evaluation required
Seizures (dose-related risk from bupropion): permanently discontinue if seizure occurs
Severe neuropsychiatric reactions (rare): psychosis, hallucinations, paranoia, severe agitation, hostility, homicidal ideation—stop medication and seek urgent care
Hypertensive reactions or significant BP/HR increases: evaluate promptly
Acute opioid withdrawal (if opioids are in the system): can be severe; avoid unsafe opioid overlap
Hepatotoxicity (naltrexone-related reports): stop if signs/symptoms of hepatitis develop
Severe hypersensitivity reactions (rare): anaphylaxis/angioedema; severe skin reactions reported with bupropion

Critical Drug Interactions

With: Opioids (including buprenorphine, methadone, and opioid pain medications)

Risk: Can precipitate acute opioid withdrawal and block opioid analgesia. Attempts to overcome blockade with high opioid doses can cause fatal overdose.

With: MAOIs (and within 14 days of MAOI use)

Risk: Serious interaction risk with bupropion; must not be combined. Contrave also must not be started in someone receiving linezolid or IV methylene blue (which act like MAOIs).

Action: Allow 14 days between stopping an MAOI and starting Contrave, and 14 days between stopping Contrave (bupropion) and starting an MAOI.

With: Other bupropion-containing products

Risk: Excess bupropion exposure increases seizure risk and adverse effects.

Action: Contraindicated. Do not combine with Wellbutrin (any formulation), Aplenzin, Zyban, or any other bupropion product.

With: Alcohol (especially heavy use or withdrawal risk)

Risk: Bupropion lowers seizure threshold. Abrupt alcohol discontinuation is a seizure risk state and is a contraindication scenario.

Action: Avoid if you’re at risk for alcohol withdrawal. Be honest about drinking patterns before starting.

With: Medications/conditions that raise seizure risk (some antipsychotics, antidepressants, theophylline, systemic corticosteroids, hypoglycemic agents)

Risk: Additive seizure risk and activation side effects (jitteriness, insomnia).

Action: Risk-screen carefully. Dose titration must be gradual; avoid stacking multiple seizure-threshold-lowering agents when possible.

With: High-fat meals

Risk: Significantly increases systemic exposure of bupropion and naltrexone, increasing adverse effect risk.

Action: Do not take with high-fat meals.

With: Thioridazine (Canadian labeling)

Risk: Additional contraindication in Canada.

Action: Avoid combination in settings where this applies.

Pregnancy, Breastfeeding, Special Groups

👶Pregnancy

🤱Breastfeeding

Not recommended while breastfeeding. Naltrexone, bupropion, and metabolites are present in breast milk; due to safety concerns, weight-loss medications are generally avoided during lactation.

👧Children & Adolescents (Under 18)

Not approved for children and teens. The antidepressant suicide-risk warning applies to children and adolescents; avoid.

👴Older Adults (65+)

🔬Liver Impairment

Mild impairment: no dosage adjustment necessary. Moderate impairment: maximum 1 tablet PO BID. Severe impairment: use is not recommended.

💧Kidney Impairment

Mild impairment: no dosage adjustment necessary. Moderate or severe impairment: maximum 1 tablet PO BID. End-stage renal disease: use is not recommended.

Clinical Monitoring

Mood and suicidality: screen for worsening depression, suicidal thoughts, and unusual behavior changes—especially in the first 1-2 months and during dose increases/decreases
Activation symptoms: anxiety, panic symptoms, agitation, irritability, hostility, impulsivity, akathisia-like restlessness
Bipolar risk: screen for bipolar disorder before starting; monitor for hypomania/mania (decreased sleep need, racing thoughts, risky behavior, grandiosity)
Sleep: insomnia severity, sleep fragmentation, and daytime fatigue (sleep disruption can destabilize mood)
Blood pressure and heart rate: baseline and periodic monitoring; risk may be higher during the first 3 months
Weight and BMI: track response and tolerability; reassess continuation at ~3 months
Blood sugar: checked at the start and from time to time if you have diabetes; watch for low blood sugar, because weight loss can make your body respond more strongly to insulin
Kidney and liver function: checked at the start and from time to time, especially if you already have kidney or liver problems
Opioid status: confirm opioid-free interval when relevant; counsel about blocked analgesia and overdose risk if attempting to override blockade
Adverse effects that change functioning: dizziness, cognitive changes, tremor, severe nausea/dehydration, mood symptoms affecting daily life

How Well It Works

Continue-or-Stop Checkpoint

4% to 5% weight loss by ~3 months

vs If below this, consider discontinuation

Mechanism of Action

Place in Treatment Algorithm

Questions people ask

Is Contrave an antidepressant?

Can Contrave help anxiety or depression?

Why does Contrave have a suicidality warning?

Can Contrave trigger insomnia or feeling “too wired”?

Is Contrave safe if I have bipolar disorder?

Can I take Contrave if I use opioid pain meds or take buprenorphine/methadone?

What’s the dosing schedule for Contrave?

How do I know if Contrave is working?

A common checkpoint is around 3 months: if you haven’t lost about 4-5% of your starting weight, it may not be worth continuing—especially if side effects are significant.

What it feels like

Cravings & Food Noise

What it's for

Naltrexone/Bupropion ER for Long-term weight management, alongside a reduced-calorie diet and more physical activity, in adults with obesity, or overweight plus at least one weight-related health problem

Side effects

Nausea

Your situation

Get help right away if

The full guide

What it's for

Taking it

Safety

How it works

Questions

What it feels like

Cravings & Food Noise

What it's for

Naltrexone/Bupropion ER for Long-term weight management, alongside a reduced-calorie diet and more physical activity, in adults with obesity, or overweight plus at least one weight-related health problem

Side effects

Nausea

Your situation

Get help right away if

The full guide

What it's for

Taking it

Safety

How it works

Questions