A combined approach where ketamine administration is integrated with structured psychotherapy sessions to enhance therapeutic outcomes, particularly for mood disorders, PTSD, and existential distress.
Reviewed by the HeyPsych Medical Review Board · Reviewed November 24, 2025
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Ketamine-Assisted Psychotherapy is used for Treatment-resistant depression. The full guide below has the details.
About Treatment-resistant depressionHow many people in 100 notice each one in clinical studies. Many early side effects fade within a few weeks.
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Avoid unless benefits outweigh risks.
General information, not advice for your case. Talk it through with your prescriber or pharmacist.
Severe agitation
Loss of consciousness
Thoughts of suicide? Call or text 988, any time.
Everything we know about Ketamine-Assisted Psychotherapy, section by section.
12 chapters · about 12 min to read it all. Open any one.
Frequency: Often 1–2 sessions per week for an initial series of 4–6; maintenance sessions scheduled as needed.
Duration: Full course can last 4–8 weeks; integration work may continue beyond pharmacologic phase.
Total Treatment Time: Each visit may last 2–3 hours including preparation and integration.
typical session cost: $400–$1,200 depending on setting and dose route
total treatment cost: $2,400–$7,200 for a standard course
insurance coverage: Often not covered unless ketamine is given for pain indications.
cost effectiveness: Can be high when sustained remission is achieved, reducing hospitalization or chronic therapy needs.
Evidence base is smaller than for IV ketamine alone; protocols vary widely between providers.
This treatment information is for educational purposes only. Treatment decisions should be made in consultation with qualified healthcare professionals based on individual circumstances, symptoms, and medical history. Do not attempt treatment without professional guidance.
Thinking about Ketamine-Assisted Psychotherapy? A prescriber can tell you if it fits.
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